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Interim influenza vaccine effectiveness: A good proxy for final estimates in Spain in the seasons 2010-2014.

Identifieur interne : 000178 ( Main/Exploration ); précédent : 000177; suivant : 000179

Interim influenza vaccine effectiveness: A good proxy for final estimates in Spain in the seasons 2010-2014.

Auteurs : Silvia Jiménez-Jorge [Espagne] ; Francisco Pozo [Espagne] ; Amparo Larrauri [Espagne]

Source :

RBID : pubmed:25869892

Descripteurs français

English descriptors

Abstract

INTRODUCTION

The agreement between interim and final influenza vaccine effectiveness (VE) estimates would support the use of interim assessments as a proxy for final VE results to guide health authorities in influenza prevention. We aimed to compare interim/final VE estimates in Spain.

METHODS

We used a test-negative case-control study (cycEVA) for 2010/11-2013/14 seasons. Sensitivity analyses were carried out by type/subtype of influenza virus and by target groups for vaccination.

RESULTS

In general, interim estimates were higher compared to end-season estimates. Interim and final VE differences were higher for the target groups compared to all population. Subtype-specific interim/final VE estimates showed greater concordance (3-13%) than for any virus (7-24%).

CONCLUSION

In Spain, interim influenza VE estimates over 2010-2014 were a good proxy of the final protection of the vaccine. Interim and final estimates showed greater concordance for all population and if performed subtype-specific.


DOI: 10.1016/j.vaccine.2015.03.051
PubMed: 25869892


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<b>INTRODUCTION</b>
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<p>The agreement between interim and final influenza vaccine effectiveness (VE) estimates would support the use of interim assessments as a proxy for final VE results to guide health authorities in influenza prevention. We aimed to compare interim/final VE estimates in Spain.</p>
</div>
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<p>
<b>METHODS</b>
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<p>We used a test-negative case-control study (cycEVA) for 2010/11-2013/14 seasons. Sensitivity analyses were carried out by type/subtype of influenza virus and by target groups for vaccination.</p>
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<b>RESULTS</b>
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<p>In general, interim estimates were higher compared to end-season estimates. Interim and final VE differences were higher for the target groups compared to all population. Subtype-specific interim/final VE estimates showed greater concordance (3-13%) than for any virus (7-24%).</p>
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<b>CONCLUSION</b>
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<p>In Spain, interim influenza VE estimates over 2010-2014 were a good proxy of the final protection of the vaccine. Interim and final estimates showed greater concordance for all population and if performed subtype-specific.</p>
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<ForeName>Nuria</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Pérez</LastName>
<ForeName>Esteban</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y">
<LastName>Gallardo</LastName>
<ForeName>Virtudes</ForeName>
<Initials>V</Initials>
</Investigator>
</InvestigatorList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2014</Year>
<Month>12</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2015</Year>
<Month>03</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2015</Year>
<Month>03</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2015</Year>
<Month>4</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2015</Year>
<Month>4</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2016</Year>
<Month>3</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">25869892</ArticleId>
<ArticleId IdType="pii">S0264-410X(15)00359-X</ArticleId>
<ArticleId IdType="doi">10.1016/j.vaccine.2015.03.051</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>Espagne</li>
</country>
<region>
<li>Communauté de Madrid</li>
</region>
<settlement>
<li>Madrid</li>
</settlement>
</list>
<tree>
<country name="Espagne">
<region name="Communauté de Madrid">
<name sortKey="Jimenez Jorge, Silvia" sort="Jimenez Jorge, Silvia" uniqKey="Jimenez Jorge S" first="Silvia" last="Jiménez-Jorge">Silvia Jiménez-Jorge</name>
</region>
<name sortKey="Larrauri, Amparo" sort="Larrauri, Amparo" uniqKey="Larrauri A" first="Amparo" last="Larrauri">Amparo Larrauri</name>
<name sortKey="Pozo, Francisco" sort="Pozo, Francisco" uniqKey="Pozo F" first="Francisco" last="Pozo">Francisco Pozo</name>
</country>
</tree>
</affiliations>
</record>

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